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Clinical evaluation of platelet concentrates stored for one to five days
CA Schiffer, EJ Lee, PM Ness and J Reilly
There are no large-scale data available describing the increments obtained
with platelet concentrates stored for varying durations. Platelet
concentrates prepared by standard techniques were stored at 22 degrees C
with horizontal agitation in PL-732 bags and administered to clinically
stable, nonalloimmunized recipients known to respond well to random donor
platelet transfusions. The platelet concentrates were stored in a mean
volume of 65.0 mL (range 54-80 mL) with an average yield of .72 X 10(11)
platelets per unit of platelet concentrates (N = 100 consecutive units).
There was no significant deterioration of pH during storage. Mean corrected
count increments ranged between 16,600 (N = 146 transfusions) after 1 day
of storage to 13,300 (N = 34 transfusions) after 5 days of storage.
Although these differences were statistically significant (P less than
.003, analysis of variance), the overall deterioration in increments was
quite modest. Platelet concentrates can be stored under standard conditions
for 1 to 5 days with acceptable clinical results.
Volume 67,
Issue 6,
pp. 1591-1594,
06/01/1986
Copyright © 1986 by The American Society of Hematology
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