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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Takahashi, M. Articles by Shibata, A. Search for Related Content PubMed PubMed Citation Articles by Takahashi, M. Articles by Shibata, A. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Immunoglobulin class switch from IgG to IgA in a patient with smoldering multiple myeloma M Takahashi, T Tsukada, M Kojima, T Koide, T Koike, H Takahashi, C Sakai, M Kashimura and A Shibata Serum of a 67-year-old male patient with smoldering multiple myeloma was shown to contain two monoclonal immunoglobulins, IgG and IgA. For the initial seven months, monoclonal IgG was predominantly elevated. During the next one year and eight months, however, serum concentration of the monoclonal IgA increased, with a concomitant decrease of IgG. N- terminal amino acid sequences of heavy and light chains separated from monoclonal IgG and IgA were analyzed. Both light chains were lambda- type and showed identical amino acid sequences of variable regions. The heavy chains also had the same N-terminal amino acid sequence between IgG and IgA. These results strongly suggest that two monoclonal proteins, IgG and IgA, in this patient were produced by B lymphocytes within a clone and that class switch from IgG to IgA in immunoglobulin production during B cell differentiation has taken place in the clinical course of this case. Volume 67, Issue 6, pp. 1710-1713, 06/01/1986 Copyright © 1986 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: P. L. Bergsagel, M. Chesi, E. Nardini, L. A. Brents, S. L. Kirby, and W. M. Kuehl Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma PNAS, November 26, 1996; 93(24): 13931 - 13936. [Abstract] [Full Text] [PDF]

	Copyright © 1986 by American Society of Hematology         Online ISSN: 1528-0020