Induction of Tac antigen and proliferation of myeloid leukemic cells by
ATL-derived factor: comparison with other agents that promote
differentiation of human myeloid or monocytic leukemic cells
S Yamamoto, T Hattori, M Matsuoka, T Ishii, N Asou, M Okada, Y Tagaya, J Yodoi and K Takatsuki
We studied seven cases of myeloid leukemia at various differentiation
stages to investigate the response of leukemic cells to phorbol 12-
myristate 13-acetate (PMA) and various biological factors. gamma-
Interferon (gamma-IFN)-treated cells expressed higher amounts of Fc
receptors on leukemic cells in five out of seven cases. Expression of
HLA-DR antigen of gamma-IFN-treated leukemic cells was significantly
enhanced in three cases. PMA did not induce Fc receptors or HLA-DR antigen
on these cells. Induction of Tac antigen, a putative interleukin 2 (IL 2)
receptor, was observed in two cases after cultivation with PMA or with a
novel lymphokine, adult T cell leukemia- derived factor (ADF). Cells from
one of these patients expressed Tac antigen immediately after cell
separation, and expression of Tac antigen was augmented by PMA and ADF.
Interleukin 1 (IL 1) or IL 2 did not induce Tac antigen. Leukemic cells
from this patient also proliferated vigorously in the presence of ADF but
not PMA, IL 1, or IL 2.
Volume 67,
Issue 6,
pp. 1714-1720,
06/01/1986
Copyright © 1986 by The American Society of Hematology
