Cytomegalovirus-specific lymphocyte proliferation and in vitro
cytomegalovirus IgG synthesis for diagnosis of cytomegalovirus infections
after bone marrow transplantation
P Ljungman, B Lonnqvist, G Gahrton, O Ringden and B Wahren
With new techniques 19 bone marrow transplant (BMT) recipients were
monitored for lymphocyte proliferation and specific IgG production in vitro
by cytomegalovirus (CMV) antigen in solid phase. Twelve patients got a
reactivated CMV infection as defined by virus isolation or serum IgG
conversion. Lymphocyte proliferation and in vitro IgG production responses
were significantly stronger in these 12 patients than in seven without
ongoing CMV infection (P = .02). CMV infection was indicated by the
lymphocyte responses at a mean of 45 days after BMT as against a mean of 79
days that passed before CMV growth in culture was detected (P less than
.05). Lymphocyte proliferation and in vitro IgG production may thus be used
as tools for diagnosis and for monitoring of CMV infections in BMT
recipients.
Volume 68,
Issue 1,
pp. 108-112,
07/01/1986
Copyright © 1986 by The American Society of Hematology
