SEARCH:   Advanced

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gralnick, H. R. Articles by Sultan, Y. Search for Related Content PubMed PubMed Citation Articles by Gralnick, H. R. Articles by Sultan, Y. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Platelet von Willebrand factor: an important determinant of the bleeding time in type I von Willebrand's disease HR Gralnick, ME Rick, LP McKeown, SB Williams, RI Parker, P Maisonneuve, C Jenneau and Y Sultan We studied 17 patients with moderate to mild type I von Willebrand's disease (vWd) and correlated the bleeding time with the plasma von Willebrand factor antigen (vWf Ag), the plasma vWf activity (ristocetin cofactor), the platelet vWf Ag, and the platelet vWf activity. We found an excellent correlation between the bleeding time and the platelet vWf activity and, to a lesser extent, between the bleeding time and the platelet vWf Ag. The length of the bleeding time was inversely proportional to the level of the platelet vWf (P less than .001) or, to a lesser extent, the platelet vWf Ag (P less than .05). The plasma vWf Ag and activity did not correlate significantly with the bleeding time. These studies indicate that the platelet vWf is one of the important bleeding time factors in type I vWd and that the platelet vWf plays an important role in the early steps of hemostasis. Volume 68, Issue 1, pp. 58-61, 07/01/1986 Copyright © 1986 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Casonato, E. Pontara, U.P. Vertolli, A. Steffan, C. Durante, L. De Marco, F. Sartorello, and A. Girolami Plasma and Platelet von Willebrand Factor Abnormalities in Patients With Uremia: Lack of Correlation With Uremic Bleeding Clinical and Applied Thrombosis/Hemostasis, April 1, 2001; 7(2): 81 - 86. [Abstract] [PDF]

	Copyright © 1986 by American Society of Hematology         Online ISSN: 1528-0020