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Lymphoepithelioid lymphoma (Lennert's lymphoma) is a monoclonal proliferation of helper/inducer T cells

AC Feller, GH Griesser, TW Mak and K Lennert

Lymphoepithelioid lymphoma (Lennert's lymphoma) was first described as a special variant of Hodgkin's disease. This lesion is characterized by a high percentage of epithelioid and T cells and rarely contains the classical Hodgkin's/Reed-Sternberg cells. Cytogenetic abnormalities indicate that Lennert's lymphoma is of T cell origin. In the present study, immunohistochemical investigation of four cases of Lennert's lymphoma revealed two major cell populations of T cells that predominantly express the helper-inducer phenotype and Ki-M6- and Ki-M8- positive macrophages and epithelioid cells. Double-staining experiments for the detection of cell surface antigens and the proliferation- associated antigen Ki67 showed that only the CD4-positive cells (helper- inducer T cells) were proliferating. Examination of the DNA of these Lennert's lymphoma samples also indicated that monoclonal rearrangement of the T cell receptor beta-chain genes has occurred, whereas the immunoglobulin heavy- and kappa-chain genes remained in germline configuration. Our results strongly suggest that Lennert's lymphoma is a CD4-positive T cell lymphoma.

Volume 68, Issue 3, pp. 663-667, 09/01/1986
Copyright © 1986 by The American Society of Hematology


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  Copyright © 1986 by American Society of Hematology         Online ISSN: 1528-0020