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Granulocyte-macrophage colony-stimulating factor enhances phagocytosis of
bacteria by human neutrophils
J Fleischmann, DW Golde, RH Weisbart and JC Gasson
In order to determine whether human granulocyte-macrophage colony-
stimulating factor (GM-CSF) can enhance phagocytosis, neutrophils were
combined with Staphylococcus aureus (S aureus), and both the number of
bacteria per neutrophil and the percent of neutrophils phagocytizing were
assessed in the absence and presence of GM-CSF. Exposure to GM-CSF did not
enable neutrophils to ingest unopsonized bacteria. When bacteria were
opsonized with serum, both the number of bacteria per neutrophil and the
percent of cells phagocytizing were increased by treatment with GM-CSF.
Digestion of extracellular organisms by lysostaphin was used to
substantiate phagocytosis. These results indicate that another effect of
GM-CSF on the mature neutrophil is the enhancement of phagocytosis.
Volume 68,
Issue 3,
pp. 708-711,
09/01/1986
Copyright © 1986 by The American Society of Hematology
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