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Autocrine growth of interleukin 2-producing leukemic cells in a patient
with adult T cell leukemia
N Arima, Y Daitoku, S Ohgaki, J Fukumori, H Tanaka, Y Yamamoto, K Fujimoto and K Onoue
Leukemic cells in the peripheral blood of a patient with adult T cell
leukemia (ATL), which expressed the Tac antigen/interleukin 2 (IL2)
receptor, were investigated in vitro for autocrine growth by IL 2. The
cells showed spontaneous proliferation in mitogen-free medium. The
spontaneous proliferation of the cells was inhibited by monoclonal anti- IL
2 or anti-Tac antibody. These cells were found to produce messenger RNA for
IL 2 and secrete IL 2 during short-term culture in the same medium.
Recombinant IL 2 and IL 2 secreted by the cells enhanced the proliferation
of the cells in a dose-dependent manner when added to the initial culture.
These findings demonstrate that an autocrine mechanism by IL 2 is involved
in the proliferation of ATL cells during short-term culture.
Volume 68,
Issue 3,
pp. 779-782,
09/01/1986
Copyright © 1986 by The American Society of Hematology
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