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Antithrombotic effect of a monoclonal antibody to the platelet glycoprotein
IIb/IIIa receptor in an experimental animal model
BS Coller, JD Folts, LE Scudder and SR Smith
A murine monoclonal antibody directed at the platelet glycoprotein IIb/IIIa
complex, which blocks platelet aggregation ex vivo, was tested for its
antithrombotic effects in an established animal model of acute platelet
thrombus formation in partially stenosed arteries. Infusion of 0.7 to 0.8
mg/kg of the F(ab')2 fragment of the antibody completely blocked new
thrombus formation despite multiple provocations, making it the most potent
antithrombotic agent tested in this model.
Volume 68,
Issue 3,
pp. 783-786,
09/01/1986
Copyright © 1986 by The American Society of Hematology
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