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Prostacyclin expression by a continuous human cell line derived from
vascular endothelium
JE Suggs, MC Madden, M Friedman and CJ Edgell
Prostacyclin is primarily an endothelial cell product. It contributes to
the important role of endothelium in maintaining the fluidity of blood by
inhibiting platelet aggregation and by promoting vasodilation. Endothelial
cells in culture tend to senesce, and the level of prostacyclin expression
decreases. A permanent human cell line, EA.hy 926, derived from a fusion of
primary endothelial cells with cells of a less differentiated line, has
been found to sustain basal and stimulated levels of prostacyclin
synthesis.
Volume 68,
Issue 4,
pp. 825-829,
10/01/1986
Copyright © 1986 by The American Society of Hematology
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