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Childhood Ki-1 lymphoma presenting with skin lesions and peripheral
lymphadenopathy
ME Kadin, D Sako, N Berliner, W Franklin, B Woda, M Borowitz, K Ireland, A Schweid, P Herzog and B Lange
We describe a large-cell lymphoma of activated lymphoid cells in six
children and adolescents. The presenting clinical features of regressing
skin lesions and peripheral lymphadenopathy, sinus infiltration of lymph
nodes, and infrequent tumor cell erythrophagocytosis resulted in initial
diagnoses of malignant or regressing atypical histiocytosis in five cases.
Binucleate and multinucleate tumor cells, sometimes with prominent
eosinophilic nucleoli, resembled Reed-Sternberg (RS) cells and occasionally
were found in a cytoarchitectural milieu that was consistent with a
diagnosis of Hodgkin's disease (HD). The tumor cells did in fact express
the HD-associated antigen Ki-1, but unlike most types of HD, the RS-like
cells expressed common leukocyte antigen and were negative for Leu-M1. A T
cell origin for the malignant cells was demonstrated with monoclonal
antibodies in two cases, by focal staining for nonspecific esterase in one
case, and by rearrangement of the beta- chain genes for the T cell receptor
in a fourth case. These studies provide further evidence that some cases
previously interpreted as malignant or regressing atypical histiocytosis
and some types of HD are actually T cell disorders.
Volume 68,
Issue 5,
pp. 1042-1049,
11/01/1986
Copyright © 1986 by The American Society of Hematology
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