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Divergent molecular phenotypes of KG1 and KG1a myeloid cell lines
AJ Furley, BR Reeves, S Mizutani, LJ Altass, SM Watt, MC Jacob, P van den Elsen, C Terhorst and MF Greaves
The cell line KG1 derived from a patient with erythroleukemia in
myeloblastic relapse has the composite phenotype and functional repertoire
of myeloblasts. In marked contrast, its subline KG1a has lost myeloid
features, acquired new karyotypic markers, and has three characteristics
associated with immature T cells: low-level expression of the T cell
receptor beta mRNA (but not alpha) transcribed from a germline gene;
high-level expression of T3 delta mRNA and intracellular, but not cell
surface, T3 protein; and expression of the CD7/gp40 T cell-associated
membrane antigen. Both KG1 and KG1a transcribe unrearranged IgH genes.
These data suggest that either the KG1 cell line was derived from a common
myeloid-lymphoid progenitor or that the KG1a subline phenotype is aberrant.
Volume 68,
Issue 5,
pp. 1101-1107,
11/01/1986
Copyright © 1986 by The American Society of Hematology
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