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Frequent and extensive deletion during the 9,22 translocation in CML
DW Popenoe, K Schaefer-Rego, JG Mears, A Bank and D Leibowitz
Chromosomal translocation is one mechanism by which cellular oncogenes may
be activated during tumorigenesis. The translocation of the abl oncogene to
the Philadelphia chromosome in chronic myelogenous leukemia (CML) results
in a new RNA transcript that fuses sequence from chromosome 22 to sequence
from the abl oncogene. This RNA presumably codes for a new abl-related
protein product found in CML, the activity of which is different from the
normal abl protein. The molecular structure of the translocation varies
from patient to patient, and the individual variation in RNA transcript and
protein product remains to be defined. This report describes the frequent
occurrence of chromosomal deletion within the 9q+ chromosome during these
translocations. The location of the deletions suggests that some mechanism
maintains the chromosomal breakpoint on the Philadelphia chromosome within
a limited region. These deletions complicate the interpretation of Southern
blots as a means of detecting the translocation.
Volume 68,
Issue 5,
pp. 1123-1128,
11/01/1986
Copyright © 1986 by The American Society of Hematology
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