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Autocrine secretion of GM-CSF in acute myeloblastic leukemia
DC Young and JD Griffin
Three cases of acute myeloblastic leukemia (AML) were identified in which
clonogenic cells proliferated autonomously in vitro. Cells from two of
these cases were found to secrete a colony-stimulating factor (CSF) that
was immunologically and molecularly related to GM-CSF. Growth of AML-CFU
could be blocked by the addition of a neutralizing antiserum to GM-CSF.
Northern blot hybridization of leukemic cell mRNA with a cDNA probe for the
GM-CSF gene revealed a 1-kb message identical in size to the normal GM-CSF
message in stimulated T cells. No GM-CSF message was detected in the third
case. These results indicate that constitutive expression of the GM-CSF
gene, apparently by leukemic cells, can result in autonomous in vitro
proliferation of AML-CFU in some cases of AML.
Volume 68,
Issue 5,
pp. 1178-1181,
11/01/1986
Copyright © 1986 by The American Society of Hematology
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