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Alpha-thalassemia in blacks: genetic and clinical aspects and interactions with the sickle hemoglobin gene

MH Steinberg and SH Embury

Recent advances in molecular genetics have permitted detailed study of the human alpha-globin genes and the causes of alpha-thalassemia. In this review, we examine the causes of alpha-thalassemia in the black population and the consequences of the interactions between alpha- thalassemia and structural hemoglobin variants.

Volume 68, Issue 5, pp. 985-990, 11/01/1986
Copyright © 1986 by The American Society of Hematology


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