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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tate, V. E. Articles by Weatherall, D. J. Search for Related Content PubMed PubMed Citation Articles by Tate, V. E. Articles by Weatherall, D. J. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  The British form of hereditary persistence of fetal hemoglobin results from a single base mutation adjacent to an S1 hypersensitive site 5' to the A gamma globin gene VE Tate, WG Wood and DJ Weatherall The G gamma and A gamma genes of an individual homozygous for the British form of A gamma nondeletion hereditary persistence of fetal hemoglobin have been cloned and partially sequenced. The G gamma gene was normal, but the A gamma gene was found to have a single base change (T----C) at -198 bp relative to the cap site. Supercoiled plasmids containing normal gamma-genes or the mutant A gamma-gene displayed an S1-hypersensitive site immediately 5' to the base change. Volume 68, Issue 6, pp. 1389-1393, 12/01/1986 Copyright © 1986 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Bacolla, M. J. Ulrich, J. E. Larson, T. J. Ley, and R. D. Wells An Intramolecular Triplex in the Human [IMAGE]-Globin 5`-Flanking Region Is Altered by Point Mutations Associated with Hereditary Persistence of Fetal Hemoglobin J. Biol. Chem., October 13, 1995; 270(41): 24556 - 24563. [Abstract] [Full Text] [PDF]

	Copyright © 1986 by American Society of Hematology         Online ISSN: 1528-0020