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Identification and characterization of a differentiation-specific antigen
on normal and malignant murine erythroid cells
ER Bacon and AJ Sytkowski
Rauscher murine erythroleukemia cells grow continuously in vitro and
undergo terminal differentiation in response to the physiological inducer
erythropoietin. In the course of this developmental process they express
many erythroid-specific markers. In order to investigate the expression of
cell surface determinants during Rauscher cell differentiation we generated
monoclonal antibodies to uninduced cells. Using an anti-Rauscher cell
monoclonal antibody, we have identified a cell surface determinant,
designated ERY-1, that is present on normal murine erythroid cells. This
determinant is apparently absent from the early progenitor BFU-E, but is
present on the more mature progenitors CFU-E and CFC-E. It disappears
during erythroid maturation and is absent from the mature erythrocyte. This
pattern of ERY-1 expression is exhibited with remarkable fidelity during
the erythropoietin-induced differentiation of Rauscher cells. Such
differentiation-specific expression of the ERY-1 determinant suggests that
it may play a functional role in erythropoiesis.
Volume 69,
Issue 1,
pp. 103-108,
01/01/1987
Copyright © 1987 by The American Society of Hematology
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