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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chilcote, R. R. Articles by Rowley, J. D. Search for Related Content PubMed PubMed Citation Articles by Chilcote, R. R. Articles by Rowley, J. D. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Association of red cell spherocytosis with deletion of the short arm of chromosome 8 RR Chilcote, MM Le Beau, C Dampier, E Pergament, Y Verlinsky, N Mohandas, H Frischer and JD Rowley Congenital spherocytic anemia is a common disorder, but in most cases the nature of the underlying membrane lesion is unknown and the genetic defect has not yet been unequivocally mapped to a chromosome. We studied two dysmorphic siblings with neurologic findings and hemolytic anemia. Clinical and laboratory findings in these two siblings were consistent with the diagnosis of congenital spherocytosis whereas both parents and two unaffected siblings were normal. The two affected children had an abnormal chromosomal complement as a result of a deletion of the short arm of chromosome 8 [(46,XX,del(8)(p11.1p21.1)]. These results suggest that a gene whose deletion results in a congenital spherocytic anemia phenotype resides on this region on the short arm of chromosome 8. Volume 69, Issue 1, pp. 156-159, 01/01/1987 Copyright © 1987 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. C. Azim, J. H. M. Knoll, A. H. Beggs, and A. H. Chishti Isoform Cloning, Actin Binding, and Chromosomal Localization of Human Erythroid Dematin, a Member of the Villin Superfamily J. Biol. Chem., July 21, 1995; 270(29): 17407 - 17413. [Abstract] [Full Text] [PDF]

	Copyright © 1987 by American Society of Hematology         Online ISSN: 1528-0020