|
|
 Previous Article | Table of Contents | Next Article 
Cytogenetic and histologic correlations in malignant lymphoma
PR Koduru, DA Filippa, ME Richardson, SC Jhanwar, SR Chaganti, B Koziner, BD Clarkson, PH Lieberman and RS Chaganti
Although a number of studies have indicated correlations between histologic
subtypes of tumors and certain nonrandom chromosome changes, cytogenetic
studies of lymphoma are in an early stage compared to those of leukemia. No
comprehensive analysis of available data has so far been attempted in the
literature either. Here we present an analysis of chromosome changes and
their correlation with subtypes of lymphoma studied by conventional
histology and cell surface markers, as observed in two sets of data: a
group of 65 karyotypically abnormal tumors sequentially ascertained and
studied by us during the period January 1, 1984 to April 30, 1985, and a
larger data set derived by combining our data with those from two published
series from the University of Minnesota that are comparable to our data.
These combined data, which comprise the largest data set on the
cytogenetics of lymphomas assembled so far, enabled a comprehensive
analysis of correlation between chromosome change and tumor histology and
the patterns of chromosome instability in these tumors. We found several
significant associations, some previously described and others now
recognized, between nonrandom chromosome gains, breaks, translocations, and
deletions and histologic subtypes of tumors that characterize lymphomas.
The data indicate that finding of chromosome breaks at certain sites (eg,
8q24, 14q32, 18q21) is of diagnostic value in dealing with cases of unusual
lymphoma. Furthermore, nonrandom chromosome breakage exhibited three
distinct patterns that reflected three levels of etiologically relevant
genetic change.
Volume 69,
Issue 1,
pp. 97-102,
01/01/1987
Copyright © 1987 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. P. Butler, S. Iida, D. Capello, D. Rossi, P. H. Rao, P. Nallasivam, D. C. Louie, S. Chaganti, T. Au, R. D. Gascoyne, et al.
Alternative Translocation Breakpoint Cluster Region 5' to BCL-6 in B-cell Non-Hodgkin's Lymphoma
Cancer Res.,
July 15, 2002;
62(14):
4089 - 4094.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Gascoyne, M. Krajewska, S. Krajewski, J. M. Connors, and J. C. Reed
Prognostic Significance of Bax Protein Expression in Diffuse Aggressive Non-Hodgkin's Lymphoma
Blood,
October 15, 1997;
90(8):
3173 - 3178.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Gascoyne, S. A. Adomat, S. Krajewski, M. Krajewska, D. E. Horsman, A. W. Tolcher, S. E. O'Reilly, P. Hoskins, A. J. Coldman, J. C. Reed, et al.
Prognostic Significance of Bcl-2 Protein Expression and Bcl-2 Gene Rearrangement in Diffuse Aggressive Non-Hodgkin's Lymphoma
Blood,
July 1, 1997;
90(1):
244 - 251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
