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Murine malaria decreases hemopoietic stem cells
PH Silverman, JC Schooley and LJ Mahlmann
The causes of anemia and immunosuppression, major outcomes of malaria, are
not well established. This study was undertaken to investigate whether
erythropoietin (EP) production is adequate and whether the hemopoietic stem
cells (CFU-S) were affected during the course of infection. Groups of
female Balb/c mice infected with Plasmodium vinckei vinckei, Plasmodium
berghei, or Plasmodium chabaudi adami were exposed to five hours of
simulated altitude equivalent to 22,000 ft. Plasma samples were collected
for EP bioassay and radioimmunoassay (RIA). Using radioiron incorporation
as an index of erythropoiesis, differences in response to infection with
different species of plasmodia were observed. In general, decreases in
erythropoietic activity were observed in bone marrow and spleen as the
infection progressed and continued to be depressed after apparent
resolution of a nonlethal infection with P. chabaudi adami. Marrow from
infected and control femurs were tested for CFU-S content using the spleen
colony assay. The cellularity and CFU-S content of the femoral marrow
decrease as the parasitemia increases. All three species of plasmodia
stimulate EP production during peak parasitemias, indicating that adequate
amounts of EP are available to the erythron during malarial infection.
Depletion of CFU-S and probable lack of compensatory turnover of CFU-S may
contribute to the disease characteristics of malaria.
Volume 69,
Issue 2,
pp. 408-413,
02/01/1987
Copyright © 1987 by The American Society of Hematology
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