|
|
 Previous Article | Table of Contents | Next Article 
bcr-abl RNA in patients with chronic myelogenous leukemia
E Shtivelman, RP Gale, O Dreazen, A Berrebi, R Zaizov, I Kubonishi, I Miyoshi and E Canaani
The major consequence of the formation of the Philadelphia (Ph1) chromosome
characteristic of leukemia cells of patients with chronic myelogenous
leukemia (CML) is fusion of c-abl and bcr genes. Using a sensitive RNase
protection technique, we analyzed mRNA from a large number of CML patients.
In most, we identified one or both species of bcr-abl chimeric transcripts.
These two mRNAs vary in the specific bcr exon joined to abl exon II and are
translated into slightly different proteins. The amounts of the fused mRNA
within leukemia cells vary considerably between individuals and do not
correlate with the phase of the disease.
Volume 69,
Issue 3,
pp. 971-973,
03/01/1987
Copyright © 1987 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
O. G. Ottmann, B. J. Druker, C. L. Sawyers, J. M. Goldman, J. Reiffers, R. T. Silver, S. Tura, T. Fischer, M. W. Deininger, C. A. Schiffer, et al.
A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias
Blood,
August 28, 2002;
100(6):
1965 - 1971.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Owen-Lynch, A. K. Y. Wong, and A. D. Whetton
v-Abl-mediated Apoptotic Suppression Is Associated with SHC Phosphorylation without Concomitant Mitogen-activated Protein Kinase Activation
J. Biol. Chem.,
March 17, 1995;
270(11):
5956 - 5962.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Tkachuk, C. Westbrook, M Andreeff, T. Donlon, M. Cleary, K Suryanarayan, M Homge, A Redner, J Gray, and D Pinkel
Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization
Science,
October 26, 1990;
250(4980):
559 - 562.
[Abstract]
[PDF]
|
|
|
|
|
