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S Pittaluga, M Uppenkamp and J Cossman
Acquisition of mature T cell function and the T cell antigen receptor
repertoire occur in the thymus. In an effort to delineate the cascade of
events leading to T cell maturation, we analyzed a series of clonal human
precursor T cell neoplasms representing early, middle, and late stages of
intrathymic differentiation. Rearrangements of the T cell receptor beta and
gamma genes appear concurrently and are preceded by surface expression of
the 3A1 (CD7) molecule. Subsequent transcription of the beta gene is
coordinated with surface expression of T1 (CD5) and T11 (CD2),
transcription of T3 delta mRNA, and the appearance of intracellular T3
(CD3) protein. As late events, T alpha gene transcripts appear and,
finally, T3, the multichain complex linked to the T cell receptor, is
presented on the cell surface. Findings reported here provide a model of
the developmental orchestration of genes encoding antigen recognition in
human T cells.
This article has been cited by other articles:
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| Copyright © 1987 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
