|
|
 Previous Article | Table of Contents | Next Article 
Mediastinal lymphoma of clear cell type is a tumor corresponding to
terminal steps of B cell differentiation
P Moller, G Moldenhauer, F Momburg, B Lammler, M Eberlein-Gonska, S Kiesel and B Dorken
This article reports eight primary mediastinal tumors occurring in young
adults (19 to 43 years, mean 29.4 years), predominantly female (six of
eight) adults. Most patients responded badly to aggressive therapy.
Progression is presently noted in one patient; five patients died 10, 11,
13, 18, and 22 months after diagnosis. No patient developed leukemia. The
tumors were highly proliferative, had a diffuse growth pattern, and
comprised clear cells of variable size. They could not be classified
histologically, but could, however, be immunohistologically characterized
as B cell lymphomas. In all cases, the immunophenotype was LC+, cALLa-,
CD19+, CD20+, CD21-, Ig (surface/cytoplasm)-, and PC-1+. In addition, the
neoplastic cells exhibited variable defects in the expression of HLA-A,B,C
and HLA-DR and inconstant expression of other B cell-restricted/associated
antigens. This combination of immunophenotypical and clinical features
suggests that the mediastinal clear cell lymphoma (MCCL) is a previously
undescribed type of B cell lymphoma corresponding to the terminal steps of
B cell differentiation.
Volume 69,
Issue 4,
pp. 1087-1095,
04/01/1987
Copyright © 1987 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. A. Shipp, S. L. Aquino, and N. L. Harris
Case 12-2005 - A 30-Year-Old Woman with a Mediastinal Mass
N. Engl. J. Med.,
April 21, 2005;
352(16):
1697 - 1704.
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Savage, S. Monti, J. L. Kutok, G. Cattoretti, D. Neuberg, L. de Leval, P. Kurtin, P. D. Cin, C. Ladd, F. Feuerhake, et al.
The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma
Blood,
December 1, 2003;
102(12):
3871 - 3879.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Copie-Bergman, M.-L. Boulland, C. Dehoulle, P. Moller, J.-P. Farcet, M. J. S. Dyer, C. Haioun, P.-H. Romeo, P. Gaulard, and K. Leroy
Interleukin 4-induced gene 1 is activated in primary mediastinal large B-cell lymphoma
Blood,
April 1, 2003;
101(7):
2756 - 2761.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Joos, C. K. Menz, G. Wrobel, R. Siebert, S. Gesk, S. Ohl, G. Mechtersheimer, L. Trumper, P. Moller, P. Lichter, et al.
Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2
Blood,
February 15, 2002;
99(4):
1381 - 1387.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Leithauser, M. Bauerle, M. Q. Huynh, and P. Moller
Isotype-switched immunoglobulin genes with a high load of somatic hypermutation and lack of ongoing mutational activity are prevalent in mediastinal B-cell lymphoma
Blood,
November 1, 2001;
98(9):
2762 - 2770.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Copie-Bergman, P. Gaulard, L. Maouche-Chretien, J. Briere, C. Haioun, M. A. Alonso, P.-H. Romeo, and K. Leroy
The MAL Gene Is Expressed in Primary Mediastinal Large B-Cell Lymphoma
Blood,
November 15, 1999;
94(10):
3567 - 3575.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
The Non-Hodgkin's Lymphoma Classification Project
A Clinical Evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin's Lymphoma
Blood,
June 1, 1997;
89(11):
3909 - 3918.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
