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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chehab, F. F. Articles by Kan, Y. W. Search for Related Content PubMed PubMed Citation Articles by Chehab, F. F. Articles by Kan, Y. W. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  The molecular basis of beta-thalassemia in Lebanon: application to prenatal diagnosis FF Chehab, V Der Kaloustian, FP Khouri, SS Deeb and YW Kan A study of the molecular lesions of beta-thalassemia in Lebanon revealed the presence of eight different mutations in 25 patients with Cooley's anemia. The IVS1 position 110 mutation predominated with a frequency of 62% and was almost invariably associated with Mediterranean chromosome haplotype I. Five other mutations commonly found in the Mediterranean area occurred with frequencies of 2% to 8%. In addition a G----C substitution in IVS1 position 5 (a lesion previously found in Chinese and Asian Indians) was demonstrated in a patient with Mediterranean haplotype IX. A new mutation at codon 29 was found in two other patients with haplotype II. The characterization of these beta-thalassemia mutations should allow the implementation of a prenatal diagnosis program in that country. Volume 69, Issue 4, pp. 1141-1145, 04/01/1987 Copyright © 1987 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Cao, L. Saba, R. Galanello, and M. C. Rosatelli Molecular Diagnosis and Carrier Screening for {beta} Thalassemia JAMA, October 15, 1997; 278(15): 1273 - 1277. [Abstract] [PDF]

	Copyright © 1987 by American Society of Hematology         Online ISSN: 1528-0020