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Mother-to-offspring transmission of human T cell leukemia virus type I in
rabbits
Y Uemura, S Kotani, S Yoshimoto, M Fujishita, M Yamashita, Y Ohtsuki, H Taguchi and I Miyoshi
We studied the mode of natural transmission of human T-cell leukemia virus
type I (HTLV-I) in rabbits. Four virus-infected rabbits (2 males and 2
females) were individually mated with 4 noninfected rabbits. Two
virus-infected females mated with noninfected males gave birth to 7
offspring, and 2 noninfected females mated with infected males delivered 5
offspring. Four of the seven offspring born to the virus- infected mothers
seroconverted for HTLV-I when aged 6 to 13 weeks with antibody titers of
1:40 to 1:160. None of the five offspring born to the noninfected mothers
became seropositive during the observation period of 6 months, however.
Peripheral lymphocytes were cultured with T cell growth factor, and
HTLV-I-carrying lymphoid cell lines were established from the four
seroconverted rabbits. All four cell lines were of T cells positive for Ia
antigens. In addition, none of five newborn rabbits killed immediately
after birth to a virus-infected rabbit was infected with HTLV-I. These
findings provide an experimental support for the milkborne transmission of
HTLV-I from mother to child in humans and indicate that the virus is tropic
for T cells in rabbits as well.
Volume 69,
Issue 4,
pp. 1255-1258,
04/01/1987
Copyright © 1987 by The American Society of Hematology
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