Chromosome aberrations and clinical features of adult T cell leukemia-
lymphoma not associated with human T cell leukemia virus type I
M Shimoyama, T Abe, K Miyamoto, K Minato, K Tobinai, H Nagoshi, M Matsunaga, T Nomura, T Tsubota and T Ohnoshi
Chromosome aberrations and clinical features of three patients with adult T
cell leukemia-lymphoma (ATL) not associated with human T cell leukemia
virus type I (HTLV-I) are described. From their clinical features, two
patients were diagnosed as acute type and one patient was diagnosed as
chronic type, which later converted to acute crisis. Clonal and many
chromosomal abnormalities were observed before therapy in the two acute
type cases and at relapse in the chronic type case. Karyotype aberrations,
including trisomy 3, trisomy 7, trisomy 21, del(6)(q21), del(10)(p13),
14q11 translocation, and loss of X chromosome, all of which are frequently
found in HTLV-I associated ATL, were also seen in these cases of
HTLV-I-negative ATL.
Volume 69,
Issue 4,
pp. 984-989,
04/01/1987
Copyright © 1987 by The American Society of Hematology
