|
|
 Previous Article | Table of Contents | Next Article 
The presence of clonogenic cells in high-grade malignant lymphoma: a
prognostic factor
ME Tweeddale, B Lim, N Jamal, J Robinson, J Zalcberg, G Lockwood, MD Minden and HA Messner
A culture system has been developed that promotes growth of clonogenic
lymphoma cells of some patients with intermediate and high-grade malignant
lymphoma. The formation of colonies in bone marrow, lymph nodes, and
peripheral blood samples is best supported by human plasma. Colony
formation of some patients was dependent upon growth factors, which in this
study were added in the form of medium conditioned by phytohemagglutinin
(PHA)-stimulated leukocytes (PHA-LCM). Some gave rise to lymphoma colonies
without PHA-LCM but improved their frequency with PHA-LCM; others were
completely independent of PHA-LCM. Colonies grown in primary cultures were
routinely recloned and propagated as Epstein-Barr virus (EBV)-negative cell
lines with stable B cell phenotype. The cell lines showed the same
immunoglobulin rearrangement pattern as that observed in the primary
lymphoma sample. In addition, a significant clinical correlation was
observed between culture data and clinical outcome. Survival of patients
who formed lymphoma colonies at any time during their clinical course was
significantly shorter than survival of patients who did not give rise to
colonies (P = 0.0009). The same observation was made when the survival
assessment was performed for the subset of patients studied at diagnosis (P
= 0.0014).
Volume 69,
Issue 5,
pp. 1307-1314,
05/01/1987
Copyright © 1987 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
Y. Kasugai, H. Tagawa, Y. Kameoka, Y. Morishima, S. Nakamura, and M. Seto
Identification of CCND3 and BYSL as Candidate Targets for the 6p21 Amplification in Diffuse Large B-Cell Lymphoma
Clin. Cancer Res.,
December 1, 2005;
11(23):
8265 - 8272.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Demers, T. Magnaldo, and Y. St-Pierre
A Novel Function for Galectin-7: Promoting Tumorigenesis by Up-regulating MMP-9 Gene Expression
Cancer Res.,
June 15, 2005;
65(12):
5205 - 5210.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ise, H. Maeda, K. Santora, L. Xiang, R. J. Kreitman, I. Pastan, and S. Nagata
Immunoglobulin Superfamily Receptor Translocation Associated 2 Protein on Lymphoma Cell Lines and Hairy Cell Leukemia Cells Detected by Novel Monoclonal Antibodies
Clin. Cancer Res.,
January 1, 2005;
11(1):
87 - 96.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Van Themsche, T. Alain, A. E. Kossakowska, S. Urbanski, E. F. Potworowski, and Y. St-Pierre
Stromelysin-2 (Matrix Metalloproteinase 10) Is Inducible in Lymphoma Cells and Accelerates the Growth of Lymphoid Tumors In Vivo
J. Immunol.,
September 15, 2004;
173(6):
3605 - 3611.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Tagawa, S. Tsuzuki, R. Suzuki, S. Karnan, A. Ota, Y. Kameoka, M. Suguro, K. Matsuo, M. Yamaguchi, M. Okamoto, et al.
Genome-Wide Array-Based Comparative Genomic Hybridization of Diffuse Large B-Cell Lymphoma: Comparison between CD5-Positive and CD5-Negative Cases
Cancer Res.,
September 1, 2004;
64(17):
5948 - 5955.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Gordon, C. M. Kanegai, J. R. Doerr, and R. Wall
Somatic hypermutation of the B cell receptor genes B29 (Igbeta , CD79b) and mb1 (Igalpha , CD79a)
PNAS,
April 1, 2003;
100(7):
4126 - 4131.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Alain, K. Hirasawa, K. J. Pon, S. G. Nishikawa, S. J. Urbanski, Y. Auer, J. Luider, A. Martin, R. N. Johnston, A. Janowska-Wieczorek, et al.
Reovirus therapy of lymphoid malignancies
Blood,
December 1, 2002;
100(12):
4146 - 4153.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Robetorye, S. D. Bohling, J. W. Morgan, G. C. Fillmore, M. S. Lim, and K. S. J. Elenitoba-Johnson
Microarray Analysis of B-Cell Lymphoma Cell Lines with the t(14;18)
J. Mol. Diagn.,
August 1, 2002;
4(3):
123 - 136.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Gilles, A. Goy, Y. Remache, P. Shue, and A. D. Zelenetz
MUC1 dysregulation as the consequence of a t(1;14)(q21;q32) translocation in an extranodal lymphoma
Blood,
May 1, 2000;
95(9):
2930 - 2936.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Stevenson, A. F. Gazdar, R. Phelps, R. I. Linnoila, D. C. Ihde, B. Ghosh, T. Walsh, E. L. Woods, H. Oie, T. O'Connor, et al.
Tumor Cell Lines Established in Vitro: An Independent Prognostic Factor for Survival in Non-Small-Cell Lung Cancer
Ann Intern Med,
November 15, 1990;
113(10):
764 - 770.
[Abstract]
[PDF]
|
|
|
|
|
|
|
N Berinstein, S Levy, and R Levy
Activation of an excluded immunoglobulin allele in a human B lymphoma cell line
Science,
April 21, 1989;
244(4902):
337 - 339.
[Abstract]
[PDF]
|
|
|
|
|
