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Ki-M8 monoclonal antibody reactive with an intracytoplasmic antigen of
monocyte/macrophage lineage
HJ Radzun, H Kreipe, S Bodewadt, ML Hansmann, J Barth and MR Parwaresch
A monoclonal antibody (MoAb), Ki-M8, that reacts specifically with cells of
the monocyte/macrophage system is described. On light and electron
microscopic immunohistochemistry, Ki-M8 recognizes intracytoplasmatically
localized antigens of mol wt 30,000 and 32,000, increasingly expressed
during differentiation of monocytes into macrophages. Ki-M8 antigen is
detectable on almost all known tissue macrophages and
monocyte/macrophage-related cell lines after appropriate stimulation. In
functional terms Ki-M8 significantly impairs the generation of oxygen
radicals during an induced respiratory burst. Applied to acute
nonlymphoblastic leukemias, a clear-cut differentiation of the monocytic
phenotype and differentiation is possible on the basis of Ki-M8
immunoreactivity. Ki-M8 represents a reagent specific for the
monocyte/macrophage system with regard to antigen distribution in normal
and neoplastic cells as well as with regard to its influence on a typical
monocyte/macrophage-related function.
Volume 69,
Issue 5,
pp. 1320-1327,
05/01/1987
Copyright © 1987 by The American Society of Hematology
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