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Differences in cell cycle characteristics among patients with acute
nonlymphocytic leukemia
A Raza, Y Maheshwari and HD Preisler
The proliferative characteristics of myeloid leukemias were defined in vivo
after intravenous infusions of bromodeoxyuridine (BrdU) in 40 patients. The
percentage of S-phase cells obtained from the biopsies (mean, 20%) were
significantly higher (P = .00003) than those determined from the bone
marrow (BM) aspirates (mean, 9%). The post- BrdU infusion BM aspirates from
40 patients were incubated with tritiated thymidine in vitro. These
double-labeled slides were utilized to determine the duration of S-phase
(Ts) in myeloblasts and their total cell cycle time (Tc). The Ts varied
from four to 49 hours (mean, 19 hours; median, 17 hours). Similarly, there
were wide variations in Tc of individual patients ranging from 16 to 292
hours (mean, 93 hours; median, 76 hours). There was no relationship between
Tc and the percentage of S-phase cells, but there was a good correlation
between Tc and Ts (r = .8). Patients with relapsed acute nonlymphocytic
leukemia (ANLL) appeared to have a longer Ts and Tc than those studied at
initial diagnosis. A subgroup of patients at either extreme of Tc were
identified who demonstrated clinically documented resistance in response to
multiple courses of chemotherapy. We conclude that Ts and Tc provide
additional biologic information that may be valuable in understanding the
variations observed in the natural history of ANLL.
Volume 69,
Issue 6,
pp. 1647-1653,
06/01/1987
Copyright © 1987 by The American Society of Hematology
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