Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SINGER, K.
Right arrow Articles by CHERNOFF, A. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SINGER, K.
Right arrow Articles by CHERNOFF, A. I.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

Blood, 1952, Vol. 7, No. 1, pp. 47-52.
© 1952 American Society of Hematology, Inc.

Studies on Abnormal Hemoglobins

III. The Interrelationship of Type S (Sickle Cell) Hemoglobin and Type F (Alkali Resistant) Hemoglobin in Sickle Cell Anemia

KARL SINGER M.D.1 and AMOZ I. CHERNOFF M.D.1

1 Department of Hematologic Research, Medical Research Institute, Michael Reese Hospital, Chicago, Ill.

1. It could be demonstrated that of the three tested types of human hemoglobin—N (normal adult), S (sickle cell) and F (fetal)—only the reduced S compound shows tactoid and gel formation in sufficiently concentrated solutions. These physico-chemical phenomena may be used for the qualitative identification of S hemoglobin.

2. The alkali resistant hemoglobin fraction, present in sickle cell anemia erythrocytes (but not in trait red cells), was concentrated in purified form. No tactoid or gel formation could be elicited. Therefore, this alkali resistant pigment does not appear to be a variant of S hemoglobin. It seems probable that sickle cell anemia erythrocytes contain two separate types of pathologic hemoglobin (S and F) which are not directly related to each other.

Submitted on June 21, 1951
Accepted on July 23, 1951


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Arch Intern MedHome page
C.-S. WRIGHT, B. SUNDHARAGIATI, J. A. BASS, and A. E. BUNNER
REVIEW OF THE 1952 HEMATOLOGY LITERATURE
Arch Intern Med, September 1, 1953; 92(3): 357 - 437.
[Abstract] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 1952 by American Society of Hematology         Online ISSN: 1528-0020