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Blood, 1952, Vol. 7, No. 6, pp. 607-612.
© 1952 American Society of Hematology, Inc.

Treatment of Paroxysmal Nocturnal Hemoglobinuria with ACTH

NORMAN KALANT M.D.1 and DONAT P. CYR M.D.1

1 Department of Internal Medicine, the Lahey Clinic, Boston, Mass.

A proven case of paroxysmal nocturnal hemoglobinuria is reported in which the patient was treated with ACTH on three occasions. Following an initial failure, the second course of ACTH resulted in a dramatic deceleration of hemolysis which, however, lasted only a short time after the cessation of treatment. A third attempt was again of no avail in relieving the condition. Treatment with dicumarol coincided with a remission of the hemolysis which has lasted, so far, for five weeks.

Submitted on December 5, 1951
Accepted on March 6, 1952


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