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HLA associations with leukemia
MM Bortin, J D'Amaro, FH Bach, AA Rimm and JJ van Rood
Frequencies of 35 HLA A, B, C, and DR antigens were determined in 1,834
leukemic Caucasoids to evaluate possible associations between HLA and
leukemia. In comparison with the frequencies of HLA antigens in published
controls, the frequency of Cw3 was significantly higher in patients with
acute lymphoblastic leukemia (relative risk = 2.64, P less than 0.0002),
acute myelogenous leukemia (relative risk = 1.92, P less than 0.0007), and
chronic myelogenous leukemia (relative risk = 2.07, P less than 0.002; P
values adjusted for multiple comparisons). The frequency of Cw4 was
elevated in patients with acute lymphoblastic leukemia (relative risk =
2.01, P less than 0.0003), acute myelogenous leukemia (relative risk =
2.06, P less than 0.0002), and chronic myelogenous leukemia (relative risk
= 2.14, P less than 0.0008). The frequency of Aw19 was significantly
decreased in patients with acute myelogenous leukemia (relative risk =
0.68, P less than 0.01) and chronic myelogenous leukemia (relative risk =
0.59, P less than 0.005). None of the other 32 HLA antigens investigated
had a statistically significant association with leukemia. The data suggest
that Cw3 and Cw4 may be markers for leukemia susceptibility genes, while
Aw19 may be a marker for decreased susceptibility to leukemia.
Volume 70,
Issue 1,
pp. 227-232,
07/01/1987
Copyright © 1987 by The American Society of Hematology
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