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Effects of B cell stimulatory factor-1/interleukin 4 on hematopoietic
progenitor cells
C Peschel, WE Paul, J Ohara and I Green
B cell stimulatory factor-1 (BSF-1)/Interleukin 4 (IL 4) is a T cell
product originally characterized on the basis of its actions on B
lymphocytes. Recently it has been reported that BSF-1 activates T cell and
mast cell lines. We now provide evidence that BSF-1, purified to
homogeneity, also has a broad spectrum of activity on hematopoietic
progenitor cells (HPC). However, like its action on B cells, prolierative
effects were only observed when BSF-1 was combined with an additional
factor. Thus BSF-1, in costimulation with recombinant G-CSF, enhances the
proliferation of granulocyte-macrophage progenitor cells (CFU-GM). BSF-1
increases the proliferation of CFU-e in the presence of recombinant
erythropoietin (rEPO). Furthermore, BSF-1 induces, together with rEPO,
colony formation by primitive erythroid (BFU-e) and multipotent (CFU-mix)
progenitor cells comparable to that observed with rEPO and interleukin 3
(IL 3). BSF-1 is also active as a megakaryocyte colony-stimulating factor;
in combination with recombinant interleukin 1, rEPO or the supernatant of
the T cell hybridoma FS7-20.6.18, BSF-1 induces megakaryocyte colony
formation (CFU-Mk). The same factors that synergize with BSF-1 also enhance
CFU-Mk proliferation induced by IL 3. Although the precise mechanisms of
action of BSF-1 on HPC is not yet known, we propose that BSF-1 represents
an activation factor for HPC and prepares the progenitor cells to respond
to specific growth or differentiation factors.
Volume 70,
Issue 1,
pp. 254-263,
07/01/1987
Copyright © 1987 by The American Society of Hematology
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