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Marrow transplantation for children with acute lymphoblastic leukemia in
second remission
JE Sanders, ED Thomas, CD Buckner and K Doney
Fifty-seven children between the ages of 3 and 17 years with acute
lymphoblastic leukemia (ALL) in chemotherapy-induced second bone marrow
remission were given cyclophosphamide, total body irradiation, and bone
marrow transplants from HLA-matched donors. Sixteen died of transplant-
related complications. Eighteen relapsed between 56 and 833 days after
transplantation, and 16 died of leukemia. Two survive in remission off
treatment following chemotherapy. Twenty-three survive in continuous
remission from 1.4 to 10.4 years after transplantation and the actuarial
analysis shows disease-free survival of 40% with a plateau extending from
2.5 to 10.4 years.
Volume 70,
Issue 1,
pp. 324-326,
07/01/1987
Copyright © 1987 by The American Society of Hematology
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