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Recombinant human TNF alpha stimulates production of granulocyte colony-
stimulating factor
HP Koeffler, J Gasson, J Ranyard, L Souza, M Shepard and R Munker
Tumor necrosis factor alpha (TNF alpha) stimulates production of
granulocyte colony-stimulating factor (G-CSF) protein and mRNA in
fibroblast cells. In contrast, TNF beta is at least 1,000-fold less potent
than TNF alpha in increasing levels of G-CSF and GM-CSF activity and mRNA.
The fibroblasts produce G-CSF and GM-CSF mRNA in a coordinate fashion after
exposure to TNF. The ability of TNF alpha to stimulate production of CSF in
fibroblasts may be pivotal to regulation of hematopoiesis.
Volume 70,
Issue 1,
pp. 55-59,
07/01/1987
Copyright © 1987 by The American Society of Hematology
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