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Intermediate- to high-grade histology of lymphomas carrying t(14;18) is
associated with additional nonrandom chromosome changes
ME Richardson, QG Chen, DA Filippa, K Offit, A Hampton, PR Koduru, SC Jhanwar, PH Lieberman, BD Clarkson and RS Chaganti
We describe additional nonrandom chromosome abnormalities in 18 cases of
intermediate- to high-grade non-Hodgkin's lymphoma (NHL) bearing t(14;18)
that were ascertained in a prospective cytogenetic study of all lymphomas
seen at Memorial Hospital during the period January 1, 1984, to December
31, 1986. These included seven cases that had histological evidence of
transformation from a lower grade and 11 that lacked such evidence. The
most common of the additional changes seen in both groups affected
chromosomes 6 and 7 and comprised the loss of chromosome 6 or del(6q) and
the presence of more than two copies of chromosome 7 or duplication of 7q.
Changes affecting these two chromosomes were less frequent in low-grade
lymphomas with t(14;18) as well as in lymphomas lacking the translocation.
These data suggest that common cytogenetic mechanisms underlie expression
of high-grade histologies by lymphomas carrying t(14;18). In addition, they
may serve as indicators of transformation when encountered in low-grade
lymphomas with t(14;18).
Volume 70,
Issue 2,
pp. 444-447,
08/01/1987
Copyright © 1987 by The American Society of Hematology
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