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Effects of herpes virus carrier status on peripheral T lymphocyte subsets
JW Gratama, AM Naipal, MA Oosterveer, T Stijnen, HC Kluin-Nelemans, LA Ginsel, GJ den Ottolander, AC Hekker, J D'Amaro and M van der Giessen
We studied the effects of herpes virus carrier status on peripheral blood T
lymphocyte subsets in 334 healthy individuals. IgG-class antibodies against
cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus
(HSV), and varicella-zoster virus (VZV) were used as markers for the
carrier status of those viruses. CMV carrier status was associated with
significant increases in the numbers of some T cell subsets, whereas the
carrier status of EBV, HSV, and VZV had no significant effects. The 159
CMV-seropositive individuals had higher numbers of HNK1+ T cells than did
the 175 CMV-seronegative individuals [mean (SD), 292 (196)/microL v 164
(89)/microL, respectively], including the CD4+HNK1+ T cells [38 (48)/microL
v 9 (13)/microL, respectively] and the CD8+HNK1+ T cells [166 (146)/microL
v 73 (54)/microL, respectively]. Morphological and cytochemical studies
showed that the expression of HNK1 by the CD4+ and CD8+ T cells was
associated with the occurrence of azurophilic cytoplasmatic granules and a
loss of nonspecific esterase activity. The numbers of CD4+HNK1+ and
CD8+HNK1+ T cells increased proportionally to the levels of the IgG- class
CMV antibody titers. We suggest that the increased numbers of CD4+HNK1+ and
CD8+HNK1+ granular T cells in CMV carriers reflect the persistent
interaction between CMV and the immune system of its hosts.
Volume 70,
Issue 2,
pp. 516-523,
08/01/1987
Copyright © 1987 by The American Society of Hematology
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