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The effects of three recombinant growth factors, IL-3, GM-CSF, and G- CSF,
on the blast cells of acute myeloblastic leukemia maintained in short-term
suspension culture
J Miyauchi, CA Kelleher, YC Yang, GG Wong, SC Clark, MD Minden, S Minkin and EA McCulloch
The blast stem cells of acute myeloblastic leukemia (AML) respond in cell
culture to growth factors by both self-renewal and terminal divisions. Both
of these functions have been shown to be stimulated by the recombinant
growth factors granulocyte-macrophage colony- stimulating factor (GM-CSF)
and granulocyte colony-stimulating factor (G-CSF). In this paper,
recombinant gibbon interleukin-3 (IL-3), homologous to human IL-3, was
tested on blast cells and compared with the effects of GM-CSF, G-CSF, and
medium conditioned by the bladder cell line 5637 (5637-CM). We found that
IL-3 was an effective stimulator of blast renewal and terminal divisions.
However, great patient-to-patient variation was found. A graphic method of
presenting complex comparisons between growth factors is also included.
Volume 70,
Issue 3,
pp. 657-663,
09/01/1987
Copyright © 1987 by The American Society of Hematology
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