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HL-60 cell line was derived from a patient with FAB-M2 and not FAB-M3
WT Dalton , MJ Ahearn, KB McCredie, EJ Freireich, SA Stass and JM Trujillo
Division of Laboratory Medicine, University of Texas M.D. Anderson Hospital
and Tumor Institute at Houston 77030.
The leukemia from which the human cell line HL-60 was derived was
classified in 1976 as acute progranulocytic leukemia (APL), although it was
recognized to show a number of atypical features. In the ensuing 10 years,
the concept of APL and its integral association with t(15;17) has evolved,
and the concept of APL as a morphologically recognizable entity has become
embodied in the term French-American-British classification M3 (FAB-M3). It
is now recognized that not every case of leukemia with a high proportion of
progranulocytes can be classified as FAB-M3. We reviewed the light and
ultrastructural morphology of the original diagnostic material from this
case, and we report that the leukemia from which HL-60 was derived does not
conform to the currently recognized entity of FAB-M3 and is more
appropriately classified as an acute myeloblastic leukemia with maturation,
FAB-M2.
Volume 71,
Issue 1,
pp. 242-247,
01/01/1988
Copyright © 1988 by The American Society of Hematology
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