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Establishment of a new Epstein-Barr virus-immortalized cell line from chronic lymphocytic leukemia with trisomy of chromosome 12 that produces monoclonal IgM against a sheep RBC antigen

M Crescenzi, M Napolitano, M Carbonari, A Antonelli, P Petrinelli, C Gaetano and M Fiorilli

Department of Clinical Immunology, University of Rome, La Sapienza, Italy.

Leukemia cells from a patient with chronic lymphocytic leukemia (CLL) were found to bind sheep RBC (SRBC) through their monoclonal surface IgM. A lymphoblastoid cell line was obtained by immortalization of leukemic cells with Epstein-Barr virus (EBV). Cultured leukemic cells were found to have a supernumerary chromosome 12, an abnormality typical of CLL of the B cell type. To our knowledge, this is the first EBV-immortalized cell line from B-CLL cells of known SRBC specificity and the third reported CLL cell line carrying trisomy of chromosome 12.

Volume 71, Issue 1, pp. 9-12, 01/01/1988
Copyright © 1988 by The American Society of Hematology


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  Copyright © 1988 by American Society of Hematology         Online ISSN: 1528-0020