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Clinical and biologic characterization of T-cell neoplasias with
rearrangements of chromosome 7 band q34
SD Smith, R Morgan, R Gemmell, MD Amylon, MP Link, C Linker, BK Hecht, R Warnke, BE Glader and F Hecht
Department of Pediatrics and Pathology, Stanford University School of
Medicine, CA.
In T cell malignancy, rearrangements of chromosome 14 have been observed
with a break in the band that contains the alpha chain gene for the T cell
receptor (TCR). Because the beta chain TCR gene is in chromosome band 7q34,
we searched for and report finding specific rearrangements of 7q34
exclusively in T cell malignancies. The rearrangements were reciprocal
translocations between 7q34 and other points: 1p34, 9q32, 9q34, 15q22, and
19p13. The malignancies containing a 7q34 translocation were either T cell
acute lymphoblastic leukemias or T cell lymphoblastic lymphomas that had
similarities in clinical, enzyme, immunologic, and cellular
characteristics. Hybridization using a probe to the beta-TCR gene disclosed
unique rearrangements consistent with clonality in every case. A common
pattern with chromosome breakpoints involving TCR genes may be emerging in
T cell neoplasia.
Volume 71,
Issue 2,
pp. 395-402,
02/01/1988
Copyright © 1988 by The American Society of Hematology
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