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Cytogenetic studies in patients with secondary leukemia/dysmyelopoietic
syndrome after different treatment modalities
J Whang-Peng, RC Young, EC Lee, DL Longo, GP Schechter and VT DeVita
Medicine Branch, National Cancer Institute, Bethesda, MD 20892.
Cytogenetic studies of 68 patients who developed secondary leukemia
(SL)/dysmyelopoietic syndrome (DMS) after extensive chemotherapy and/or
radiation therapy as well as patients who developed SL/DMS without such
treatment showed that those patients who received radiation alone or with
chemotherapy had more extensive numerical and structural abnormalities than
those who received only chemotherapy. In terms of the specific chromosomal
abnormalities, there are no differences between the various treatment
groups. Hypodiploidy is the most common form of aneuploidy in these
patients, with the most common numerical abnormality being the loss of
chromosome 7. The most common structural abnormalities involved chromosomes
3 and 5. When compared with patients with de novo leukemia and DMS, the
chromosomal abnormalities in these patients are more complex and extensive.
Serial studies revealed that cytogenetic abnormalities do not precede the
development of hematologic changes by significant time periods.
Volume 71,
Issue 2,
pp. 403-414,
02/01/1988
Copyright © 1988 by The American Society of Hematology
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