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Interleukin 1 induces human marrow stromal cells in long-term culture to
produce granulocyte colony-stimulating factor and macrophage colony-
stimulating factor
WE Fibbe, J van Damme, A Billiau, HM Goselink, PJ Voogt, G van Eeden, P Ralph, BW Altrock and JH Falkenburg
Laboratory of Experimental Hematology, J.A. Cohen Institute for
Radiopathology and Radiation Protection, Leiden, The Netherlands.
Pure interleukin 1 (IL 1) was found to stimulate established human bone
marrow stromal layers in long-term culture to produce colony- stimulating
activity (CSA). Maximal concentrations in the culture medium were reached
24 hours after a single IL 1 pulse. The effect could be neutralized by a
specific rabbit anti-IL 1 antiserum. Stromal layers, once stimulated by IL
1, continued to release CSA into the culture medium in the absence of
exogenous IL 1. A second IL 1 pulse induced CSA release in an identical
manner, as did the primary stimulation, indicating that the CSA released
was actively produced. Using specific immunologic assays, both granulocyte
colony-stimulating factor (G-CSF) and macrophage CSF (M-CSF) could be
identified in the culture supernatants, and production of both factors was
inducible by IL 1. Shortly after initiation of the long-term marrow
cultures "spontaneous" G-CSF and M-CSF release occurred. The release of
G-CSF diminished following addition of the anti-IL 1 antiserum, indicating
that endogenous production of IL 1 by stromal cells had contributed to this
effect. These results further support the role of IL 1 as an important
modulator of CSF production by cells of the hematopoietic microenvironment.
Volume 71,
Issue 2,
pp. 430-435,
02/01/1988
Copyright © 1988 by The American Society of Hematology
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