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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kulozik, A. E. Articles by Weatherall, D. J. Search for Related Content PubMed PubMed Citation Articles by Kulozik, A. E. Articles by Weatherall, D. J. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  The molecular basis of alpha thalassemia in India. Its interaction with the sickle cell gene AE Kulozik, BC Kar, GR Serjeant, BE Serjeant and DJ Weatherall Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, England. The alpha globin genotype of a total of 282 Indians from Orissa state has been analyzed. The overall alpha thalassemia gene frequency is 0.29, most frequently caused by the -alpha 3.7 and -alpha 4.2 deletions. In one family a novel -alpha 3.5 deletion removing the alpha 1 globin gene with some of its flanking sequences has been found, suggesting further sequence homology of the alpha globin gene cluster 3' to the alpha 1 globin gene. Patients with sickle cell disease and alpha thalassemia had higher hemoglobin (Hb) levels, RBC counts, and Hb A2 levels, and lower reticulocyte counts, MCV, MCH, and Hb F levels than those with a normal alpha genotype. The frequency of splenomegaly was not influenced by the alpha globin genotype. A higher prevalence of alpha thalassemia was found in patients greater than or equal to 10 years of age than in the younger group, suggesting a possible advantageous effect of alpha thalassemia on the survival of patients with sickle cell disease. Volume 71, Issue 2, pp. 467-472, 02/01/1988 Copyright © 1988 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. J. Rugless, C. A. Fisher, J. M. Old, J. Sloane-Stanley, H. Ayyub, D. R. Higgs, and D. Garrick A large deletion in the human {alpha}-globin cluster caused by a replication error is associated with an unexpectedly mild phenotype Hum. Mol. Genet., October 1, 2008; 17(19): 3084 - 3093. [Abstract] [Full Text] [PDF]

	Copyright © 1988 by American Society of Hematology         Online ISSN: 1528-0020