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Variation of class I HLA antigen expression among platelet density cohorts: a possible index of platelet age?

J Pereira, C Cretney and RH Aster

Center of Southeastern Wisconsin, Milwaukee 53233.

Platelet alloantigens and other surface markers were studied in platelet cohorts of different mean density, using monoclonal and polyclonal probes. High density (HD) platelets expressed 12% more P1A1 molecules (46,942) than low density (LD) platelets (41,892). However, LD platelets carried 42% more HLA-A2 molecules (6,267 +/- 184) than HD platelets (4,406 +/- 232) (P less than .01) and 55% more class I HLA antigens (17,034 +/- 2,062 v 11,007 +/- 2,190) (P = .05). The platelet subpopulations did not differ in their content of glycoprotein (GP)IIb/IIIa complex or Baka antigen. The difference in expression of class I HLA antigens on HD and LD platelets is consistent with two possibilities: either class I HLA molecules are acquired from plasma or they are released into plasma as platelets age in circulation. Accordingly, class I HLA molecules may provide a useful marker of platelet age.

Volume 71, Issue 2, pp. 516-519, 02/01/1988
Copyright © 1988 by The American Society of Hematology


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C. Gouttefangeas, M. Diehl, W. Keilholz, R. F. Hornlein, S. Stevanovic, and H.-G. Rammensee
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  Copyright © 1988 by American Society of Hematology         Online ISSN: 1528-0020