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Localization of erythropoietin synthesizing cells in murine kidneys by in
situ hybridization
ST Koury, MC Bondurant and MJ Koury
Vanderbilt University Medical Center, Nashville, TN.
In situ hybridization was used to localize the cells that produce
erythropoietin (EP) in anemic murine kidneys. Kidneys from anemic and
nonanemic mice were fixed and processed for paraffin embedding. Sections
were hybridized with a 35S-labeled RNA probe complementary to mRNA coding
for EP. An uncommon, but specific type of cell was intensely labeled in the
cortices of anemic kidneys. The labeled cells were clearly nonglomerular
and nontubular. Their location outside of the tubular basement membrane was
consistent with that of a subset of interstitial cells or capillary
endothelial cells.
Volume 71,
Issue 2,
pp. 524-527,
02/01/1988
Copyright © 1988 by The American Society of Hematology
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