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Introduction of interleukin-3 gene into stromal cells from the bone marrow
alters hemopoietic differentiation but does not modify stem cell renewal
D Zipori and F Lee
Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Cloned endothelial-adipocytes from the stroma of mouse bone marrow
(designated 14F1.1) induced growth of stem cells in vitro, accompanied by
either pre-B lymphopoiesis or myelopoiesis. We examined the contribution of
colony stimulating factors (CSF) to the process. mRNA for GM-CSF,
interleukin 3 (IL3), G-CSF, and IL4 could not be detected in the stromal
cells. Expression of IL3 gene, achieved by transfection of 14F1.1 cells
with a plasmid carrying an IL3 cDNA, shifted the direction of
differentiation but did not improve stem cell maintenance. It is proposed
that novel stromal cell factors, distinct from known CSFs, regulate stem
cell renewal.
Volume 71,
Issue 3,
pp. 586-596,
03/01/1988
Copyright © 1988 by The American Society of Hematology
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