|
|
 Previous Article | Table of Contents | Next Article 
Evidence for tissue factor-dependent activation of the classic extrinsic
coagulation mechanism in blood obtained from bleeding time wounds
HJ Weiss and B Lages
Department of Medicine, St Luke's-Roosevelt Hospital Center, New York, NY
10019.
The activation of platelets and the coagulation mechanism was studied by
collecting blood from a standard bleeding time incision at 30-second
intervals and measuring the plasma concentrations of fibrinopeptide A
(FPA), platelet factor 4 (PF4), and thromboxane B2 (TxB2). FPA was observed
in the first samples (30 to 60 seconds) obtained, increased progressively
until cessation of bleeding, and was markedly diminished after heparin
administration, thus indicating that thrombin formation occurs early in
incisional blood. PF4 increased monotonically throughout blood sampling,
whereas the major increase in TxB2 appeared near the cessation of bleeding.
The initial increase in FPA content occurred normally in patients with
deficiencies of either factor IX or VIII, was markedly diminished in
patients with factor X or V deficiency, and was delayed in patients with
factor VII deficiency. These studies suggest that tissue factor activation
of the classic (activation of factor X) extrinsic coagulation mechanism
occurs as an early event during the arrest of bleeding from bleeding time
incisions. The relation of the aforementioned to platelet activation is
less clear because there was no consistent correlation between decreased
FPA formation and impaired PF4 secretion or TxB2 production. In fact, the
latter were normal in some subjects with the most impaired FPA formation,
which suggests that both collagen and thrombin, perhaps synergistically,
may contribute to platelet activation during the primary arrest of
bleeding.
Volume 71,
Issue 3,
pp. 629-635,
03/01/1988
Copyright © 1988 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. Hoffman, A. Harger, A. Lenkowski, U. Hedner, H. R. Roberts, and D. M. Monroe
Cutaneous wound healing is impaired in hemophilia B
Blood,
November 1, 2006;
108(9):
3053 - 3060.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Undas, K. E. Brummel-Ziedins, and K. G. Mann
Statins and Blood Coagulation
Arterioscler. Thromb. Vasc. Biol.,
February 1, 2005;
25(2):
287 - 294.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. C. Sarich, M. Wolzt, U. G. Eriksson, C. Mattsson, A. Schmidt, S. Elg, M. Andersson, M. Wollbratt, G. Fager, and D. Gustafsson
Effects of ximelagatran, an oral direct thrombin inhibitor, r-hirudin and enoxaparin on thrombin generation and platelet activation in healthy male subjects
J. Am. Coll. Cardiol.,
February 19, 2003;
41(4):
557 - 564.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Undas, W. J. Sydor, K. Brummel, J. Musial, K. G. Mann, and A. Szczeklik
Aspirin Alters the Cardioprotective Effects of the Factor XIII Val34Leu Polymorphism
Circulation,
January 7, 2003;
107(1):
17 - 20.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. N. Wilcox, S. Noguchi, and J. Casanova
Extrahepatic Synthesis of Factor VII in Human Atherosclerotic Vessels
Arterioscler. Thromb. Vasc. Biol.,
January 1, 2003;
23(1):
136 - 141.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Diaz-Ricart, G. Arderiu, E. Estebanell, S. Perez-Pujol, M. Lozano, J. G. White, G. Escolar, and A. Ordinas
Inhibition of Cytoskeletal Assembly by Cytochalasin B Prevents Signaling Through Tyrosine Phosphorylation and Secretion Triggered by Collagen but Not by Thrombin
Am. J. Pathol.,
January 1, 2002;
160(1):
329 - 337.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Undas, K. Brummel, J. Musial, K. G. Mann, and A. Szczeklik
PlA2 Polymorphism of {beta}3 Integrins Is Associated With Enhanced Thrombin Generation and Impaired Antithrombotic Action of Aspirin at the Site of Microvascular Injury
Circulation,
November 27, 2001;
104(22):
2666 - 2672.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Undas, K. Brummel, J. Musial, K. G. Mann, and A. Szczeklik
Blood coagulation at the site of microvascular injury: effects of low-dose aspirin
Blood,
October 15, 2001;
98(8):
2423 - 2431.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Undas, K. E. Brummel, J. Musial, K. G. Mann, and A. Szczeklik
Simvastatin Depresses Blood Clotting by Inhibiting Activation of Prothrombin, Factor V, and Factor XIII and by Enhancing Factor Va Inactivation
Circulation,
May 8, 2001;
103(18):
2248 - 2253.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Inoue, H. Wada, M. Takagi, M. Yamamuro, K. Mukai, T. Nakasaki, M. Shimura, K. Hiyoyama, H. Deguchi, E. C. Gabazza, et al.
Hemostatic Abnormalities in Patients With Thrombotic Complications on Maintenance Hemodialysis
Clinical and Applied Thrombosis/Hemostasis,
April 1, 2000;
6(2):
100 - 103.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T. Nakasaki, H. Wada, R. Watanabe, Y. Mori, E. C. Gabazza, S. Kageyama, M. Nishikawa, and H. Shiku
State-of-the-Art Review : Elevated Tissue Factor Levels in Leukemic Cell Homogenate
Clinical and Applied Thrombosis/Hemostasis,
January 1, 2000;
6(1):
14 - 17.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Weltermann, M. Wolzt, K. Petersmann, C. Czerni, U. Graselli, K. Lechner, and P. A. Kyrle
Large Amounts of Vascular Endothelial Growth Factor at the Site of Hemostatic Plug Formation In Vivo
Arterioscler. Thromb. Vasc. Biol.,
July 1, 1999;
19(7):
1757 - 1760.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Szczeklik, J. Musial, A. Undas, P. Gajewski, P. Gora, J. Swadzba, and M. Jankowski
Inhibition of thrombin generation by simvastatin and lack of additive effects of aspirin in patients with marked hypercholesterolemia
J. Am. Coll. Cardiol.,
April 1, 1999;
33(5):
1286 - 1293.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Wakita, H. Wada, T. Nakase, T. Nakasaki, M. Shimura, K. Hiyoyama, Y. Mori, E. C. Gabazza, M. Nishikawa, K. Deguchi, et al.
Aberrations of the Tissue Factor Pathway in Patients Positive for Lupus Anticoagulant
Clinical and Applied Thrombosis/Hemostasis,
January 1, 1999;
5(1):
10 - 15.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K. Krejcy, L. Schmetterer, J. Kastner, M. Nieszpaur-Los, B. Monitzer, W. Schutz, H.-G. Eichler, and P. A. Kyrle
Role of Nitric Oxide in Hemostatic System Activation In Vivo in Humans
Arterioscler. Thromb. Vasc. Biol.,
November 1, 1995;
15(11):
2063 - 2067.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. Eichinger, M. Wolzt, B. Schneider, M. Nieszpaur-Los, H. Heinrichs, K. Lechner, H.-G. Eichler, and P. A. Kyrle
Effects of Recombinant Hirudin (r-Hirudin, HBW 023) on Coagulation and Platelet Activation In Vivo : Comparison With Unfractionated Heparin and a Low-Molecular-Weight Heparin Preparation (Fragmin)
Arterioscler. Thromb. Vasc. Biol.,
July 1, 1995;
15(7):
886 - 892.
[Abstract]
[Full Text]
|
|
|
|
|
