|
|
 Previous Article | Table of Contents | Next Article 
Autologous peripheral hematopoietic stem cell transplantation restores
hematopoietic function following marrow ablative therapy
A Kessinger, JO Armitage, JD Landmark, DM Smith and DD Weisenburger
Department of Internal Medicine, University of Nebraska Medical Center,
Omaha 68105.
From ten patients with advanced malignant disease involving the bone
marrow, autologous hematopoietic stem cells were collected from the
peripheral blood during eight four-hour pheresis procedures and
cryopreserved. No manipulations to increase the number of stem cells
circulating in the blood were used during the collections. Following marrow
ablative chemotherapy or chemoradiotherapy, the autologous cells were
thawed and infused intravenously (IV). WBCs reappeared in the circulation
at a median of eight days (range seven to 11 days) after stem cell
infusion. Two patients died early, whereas the other eight reached normal
numbers of circulating granulocytes that have persisted for up to greater
than 20 months. These eight patients became independent of RBC transfusions
(hemoglobin concentration greater than 10 g/dL) at a median of 27 days
(range 11 to 58 days) after transplantation. One patient received platelet
transfusions for counts less than 50 x 109)/L, one patient developed a
clinical picture of idiopathic thrombocytopenic purpura, and six patients
maintained a platelet count greater than 20 x 10(9)/L at a median of 23
days (range 14 to 25 days) following stem cell infusion. This technique
allows patients ineligible for autologous bone marrow transplantation due
to unacceptable anesthetic risks, prior pelvic irradiation, or bone marrow
metastases to receive marrow ablative therapy.
Volume 71,
Issue 3,
pp. 723-727,
03/01/1988
Copyright © 1988 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
E. Balducci, G. Azzarello, M. T. Valenti, G. M. Capuzzo, G. L. Pappagallo, I. Pilotti, S. Ausoni, M. Bari, F. Rosetti, D. Sartori, et al.
The Impact of Progenitor Enrichment, Serum, and Cytokines on the Ex Vivo Expansion of Mobilized Peripheral Blood Stem Cells: A Controlled Trial
Stem Cells,
January 1, 2003;
21(1):
33 - 40.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Mink and J. O. Armitage
High-Dose Therapy in Lymphomas: A Review of the Current Status of Allogeneic and Autologous Stem Cell Transplantation in Hodgkin's Disease and Non-Hodgkin's Lymphoma
Oncologist,
June 1, 2001;
6(3):
247 - 256.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Brasel, H. J. McKenna, K. Charrier, P. J. Morrissey, D. E. Williams, and S. D. Lyman
Flt3 Ligand Synergizes With Granulocyte-Macrophage Colony-Stimulating Factor or Granulocyte Colony-Stimulating Factor to Mobilize Hematopoietic Progenitor Cells Into the Peripheral Blood of Mice
Blood,
November 1, 1997;
90(9):
3781 - 3788.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L.B. To, D.N. Haylock, P.J. Simmons, and C.A. Juttner
The Biology and Clinical Uses of Blood Stem Cells
Blood,
April 1, 1997;
89(7):
2233 - 2258.
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Lefebvre, J.N. Winter, A.W. Rademaker, C. Goolsby, and I. Cohen
In Vitro Production of Megakaryocytes from PIXY321 versus GM-CSF-Mobilized Peripheral Blood Progenitor Cells
Stem Cells,
March 1, 1997;
15(2):
112 - 118.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. K.W. Lie and L. B. To
Peripheral Blood Stem Cells: Transplantation and Beyond
Oncologist,
February 1, 1997;
2(1):
40 - 49.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Schattner, P Lefebvre, S. Mingolelli, C. Goolsby, A Rademaker, J. White, D Foster, D Green, and I Cohen
Thrombopoietin-stimulated ex vivo expansion of human bone marrow megakaryocytes
Stem Cells,
March 1, 1996;
14(2):
207 - 214.
[Abstract]
|
|
|
|
|
|
|
J. O. Armitage
Bone Marrow Transplantation
N. Engl. J. Med.,
March 24, 1994;
330(12):
827 - 838.
[Full Text]
|
|
|
|
|
|
|
M Gabbianelli, M Sargiacomo, E Pelosi, U Testa, G Isacchi, and C Peschle
"Pure" human hematopoietic progenitors: permissive action of basic fibroblast growth factor
Science,
September 28, 1990;
249(4976):
1561 - 1564.
[Abstract]
[PDF]
|
|
|
|
|
