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The effect of erythroid hyperplasia on iron balance
P Pootrakul, K Kitcharoen, P Yansukon, P Wasi, S Fucharoen, P Charoenlarp, G Brittenham, MJ Pippard and CA Finch
Department of Medicine, Siriraj Hospital, Bangkok, Thailand.
Measurements of erythropoiesis and iron balance were made in eight normal
and 32 anemic subjects. The latter consisted of 12 individuals with
ineffective erythropoiesis (beta-thalassemia/hemoglobin E), 13 subjects
with ineffective erythropoiesis and hemolytic anemia (hemoglobin H), and
seven subjects with hemolytic anemia (hereditary spherocytosis). A
consistent relationship within each group existed between the degree of
erythropoiesis and radioiron absorption. Although the effect of
erythropoiesis on iron absorption was of similar magnitude in the two
thalassemia groups, the effect in hereditary spherocytosis was much less.
There was agreement between absorption and ferritin or magnetic
susceptibility (SQUID) measurements of iron stores in thalassemia, but in
hereditary spherocytosis a discrepancy existed between absorption and
ferritin. It is concluded that, although increased erythropoiesis is
associated with increased iron absorption, some additional factor
associated with red cell breakdown is more directly responsible for the
positive iron balance in thalassemia.
Volume 71,
Issue 4,
pp. 1124-1129,
04/01/1988
Copyright © 1988 by The American Society of Hematology
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